David Kulp and Oliver Brock's group (UMass Computer Science) is interested in diverse topics including microarray resequencing by hybridization, protein folding, alternative splicing, and regulatory networks.

Mike Henson's group (UMass Chemical Engineering) works on modeling of complex dynamical systems including microbial cell populations and avacular tumors.

Hava Siegelmann (UMass Computer Science) simulates circadian oscillators by dynamic gene networks and collaborates on computational neurobiology.

Moon Kim's group (UMass Mechanical and Industrial Engineering) works on protein folding and dynamics.

Illeana Steinu is a computational geometer at Smith who is working on protein folding.

Erin Conlon (UMass Math & Statistics) works on microarray analysis methods.

The Geobacter project in Derek Lovley's lab (UMass Microbiology) is working on computational models of the Geobacter metabolism. Bioinformatics activities include genome assembly, annotation, and functional predictions from microarray expression experiments.

Jeff Blanchard (UMass Microbiology) uses systems-level approaches to understand bacterial stress response networks related to host-pathogen interactions and the influence of global climate change on populations of marine cyanobacteria and communities of bacteria. Genome sequences and microarray data are important data sources.

Lila Gierasch group in (UMass Biochemistry) studies how amino acid sequence determines the three-dimensional structure of a protein. This problem is addressed in the laboratory through the study of how conformational preferences of model peptides guides folding. Detailed studies of in vitro folding of a predominantly b-sheet protein with a very simple topology are also carried out. Methods of use in all of the folding work include circular dichroism, fluorescence, and nuclear magnetic resonance.

Eric Martz (UMass Microbiology) and his group develop macromolecular 3D structure visualization software for education and researchers, notably ProteinExplorer.org, the ConSurf Server for identifying evolutionarily conserved surface patches on proteins, and the The World Index of Molecular Visualization Resources, which along with many other educational tutorials are available through the U Mass umbrella site MolviZ.Org.